Ellenor is called to the house of her close friend, Senator Keith Ellison, where she finds the dead body of a man in his bed. The senator claims to shooting the man, thinking he was raping his wife, not realizing they're actually having an affair. In a sensational trial, full of twists and turns, Helen and new ADA Alan Lowe try to prove the senator murdered the man in a fit of rage - but no one is ready for the real truth behind this crime.

《律师本色第六季》讲述了男主在命运的驱使下，闯入制毒贩毒的毒枭集团，进而利用超凡的化学专业知识和过人的胆识，成为缉毒第一线的功勋卧底的故事，该剧以80%的超高还原度，弱化了破案过程的纪实描写， 加大了推理、悬疑氛围的营构， 获得了原著党们的认可。